Relation of Serum Vitamin D Level with Parkinson’s Disease

Objective: Few studies have been conducted globally to find out the relationship between serum vitamin D level and Parkinson’s Disease. The recent study was aimed to find out the relation of serum vitamin D level with Parkinson’s disease.

Methods: This cross-sectional comparative study was carried out in the Department of Neurology, Mymensingh Medical College Hospital, Mymensingh, Bangladesh during January 2019 to December 2020. A total of 55 Parkinson’s disease patients diagnosed on the basis of UK Brain Bank criteria and age and sex matched 55 apparently healthy individuals were enrolled in this study. Cases of secondary Parkinsonism, individuals with comorbidities which can affect serum vitamin D level and recent vitamin D supplementation were excluded.

Results: Both patient and healthy group were analyzed against different socio-demographic variables. After Hoehn and Yahr staging, most of the cases were in stage 2 and stage 3 (30.91%). In PD group 27 patients (49.09%) and in healthy group 10 individuals (18.18%) had insufficient serum vitamin D level (10-20 ng/ml). 05 patients in case group and 3 individuals in control group had deficient serum vitamin D levels. Significant difference (p<0.001) between mean serum vitamin D levels were found between cases (20.86±9.43 ng/ml) and controls (29.32±9.96 ng/ml). There were statistically insignificant progressively lower serum vitamin D levels with increased disease severity.

Conclusion: These findings may prompt adjunctive therapeutic decisions about vitamin D supplementation in PD.